HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylcarbodiimide → N-{4-Chloro-3-[5-chloro-6-(3-cyano-pyrrolidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}2,2-dimethyl-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | 1-(4,5-Diamino-2-chloro-phenyl)-pyrrolidine-3-carbonitrile | HCID 67957678 | — |
| Reactant | HCID 86646343 | HCID 86646343 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-{4-Chloro-3-[5-chloro-6-(3-cyano-pyrrolidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}2,2-dimethyl-propionamide | HCID 178447320 | — |
Reaction Steps
The title compound was prepared from N-(4-chloro-3-isothiocyanatobenzyl)-2,2-dimethyl-propionamide (66 mg, 0.2 mmol), 1-(4,5-diamino-2-chloro-phenyl)-pyrrolidine-3-carbonitrile (55 mg, 0.2 mmol) in DMF (2 mL) and DIC (39 μL, 0.2 mmol) in analogy to example 6 step (c).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466186B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-81e4e20bb9eb471286222c250654bf03 |
| Source note | uspto-grants-2013_06 |