HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (R)-1-(5-Amino-2-chloro-4-nitro-phenyl)-2-hydroxymethyl-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4,5-Dichloro-2-nitroaniline | HCID 81149 | — |
| Reactant | Prolinol, (R)- | HCID 2724541 | — |
| Reactant | Trifluoroacetic acid water | HCID 22392675 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (R)-1-(5-Amino-2-chloro-4-nitro-phenyl)-2-hydroxymethyl-pyrrolidine | HCID 67957823 | — |
Reaction Steps
(R)-2-Hydroxymethyl-pyrrolidine (202 mg, 2.0 mmol) followed by potassium carbonate (304 mg, 2.2 mmol) were added to a mixture of 4,5-dichloro-2-nitro-phenylamine (414 mg, 2.0 mmol) in DMF (10 mL) and stirred at rt overnight. The reaction mixture was diluted with water, acidified with TFA:H2O 1:1 and filtered. The filtercake was washed with DMF:H2O 1:1 and dried to give the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466186B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-5c4a171d562141d3b810991ad0bbb110 |
| Source note | uspto-grants-2013_06 |