HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-1-(5-Amino-2-chloro-4-nitro-phenyl)-2-hydroxymethyl-pyrrolidine → (R)-1-(4,5-Diamino-2-chloro-phenyl)-2-hydroxymethyl-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-1-(5-Amino-2-chloro-4-nitro-phenyl)-2-hydroxymethyl-pyrrolidine | HCID 67957823 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (R)-1-(4,5-Diamino-2-chloro-phenyl)-2-hydroxymethyl-pyrrolidine | HCID 67957655 | — |
Reaction Steps
The sub-title compound was prepared from (R)-1-(5-amino-2-chloro-4-nitro-phenyl)-2-hydroxymethyl-pyrrolidine (220 mg, 0.8 mmol) and Pt/C (50 mg) in MeOH (6 mL) and THF (6 mL) in analogy to example 1 step (f).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466186B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-6d379693877740519649ecd850e58b85 |
| Source note | uspto-grants-2013_06 |