HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4-Chloro-5-morpholin-4-yl-2-nitro-N-methyl-aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4,5-Dichloro-n-methyl-2-nitroaniline | HCID 289317 | — |
| Reactant | Trifluoroacetic acid water | HCID 22392675 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Chloro-5-morpholin-4-yl-2-nitro-N-methyl-aniline | HCID 44120648 | — |
Reaction Steps
Morpholine (174 mg, 2.0 mmol) followed by potassium carbonate (304 mg, 2.2 mmol) were added to a mixture of 4,5-dichloro-N-methyl-2-nitroaniline (442 mg, 2.0 mmol) in DMF (10 mL) and stirred at rt overnight. The reaction mixture was acidified with TFA:H2O 1:1 and purified by chromatography to give the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466186B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-dea7111d858740d4a988ebb0ef94247b |
| Source note | uspto-grants-2013_06 |