HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → N-{4-Chloro-3-[5-chloro-1-methyl-6-(4-methyl-piperazin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 5-Chloro-2-methylamino-4-(4-methyl-piperazin-1-yl)-aniline | HCID 67957923 | — |
| Reactant | N-(4-Chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide | HCID 86646336 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-{4-Chloro-3-[5-chloro-1-methyl-6-(4-methyl-piperazin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanecarboxamide | HCID 60162660 | — |
Reaction Steps
The title compound was prepared from N-(4-chloro-3-isothiocyanato-benzyl)-1-trifluoromethyl-cyclopropanecarboxamide (176 mg, 0.5 mmol), 5-chloro-2-methylamino-4-(4-methyl-piperazin-1-yl)-aniline (134 mg, 0.5 mmol) and EDC (93 μL, 0.5 mmol) in MeCN (5 mL) in analogy to example 1 step (g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466186B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-52d61bce60124560bec79918888a27b5 |
| Source note | uspto-grants-2013_06 |