HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → N-{2,4-Dichloro-3-[5-chloro-1-methyl-6-(3-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclobutanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 1-(Trifluoromethyl)cyclobutanecarboxylic acid | HCID 2782838 | — |
| Reactant | 2,4-Dichloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl)piperidin-1-yl)-1H-benzimidazol-2-ylamino]benzylamine | HCID 86674335 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-{2,4-Dichloro-3-[5-chloro-1-methyl-6-(3-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclobutanecarboxamide | HCID 88538224 | — |
Reaction Steps
The title compound was prepared from TBTU (35 mg, 0.11 mmol), TEA (50 μL, 0.36 mmol), 1-trifluormethyl-cyclobutanecarboxylic acid (57 mg, 0.4 mmol) and 2,4-dichloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl)piperidin-1-yl)-1H-benzimidazol-2-ylamino]benzylamine (45.3 mg, 0.1 mmol) in DMF (3 mL) analogy to example 1 step (i).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466186B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-6d323e32c57a4a44871d44b75eb86c4c |
| Source note | uspto-grants-2013_06 |