反应详情

Acetylchloride (2.56 mL, 36.0 mmol) was added to a mixture of 6-chloro-2-fluoro-3-methyl-aniline (5.00 g, 31.3 mmol) and toluene (200 mL), additional toluene (50 mL) was added and the mixture was heated to reflux for 3 h. The reaction mixture was cooled with an ice bath and the formed precipitate was filtered off, washed with cold toluene and dried.

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureto reflux for 3 h
4. temperatureThe reaction mixture was cooled with an ice bath
5. filtrationthe formed precipitate was filtered off
6. washwashed with cold toluene
7. customdried