Pivaloyl chloride → N-(3-amino-4-chloro-2-fluorobenzyl)pivalamide

HRID 1258687Notes

Reaction equation

[NH2:1][C:2]1[C:3]([F:11])=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH2:6].[CH3:12][C:13]([CH3:18])([CH3:17])[C:14](Cl)=[O:15]>>[NH2:1][C:2]1[C:3]([F:11])=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH:6][C:14](=[O:15])[C:13]([CH3:18])([CH3:17])[CH3:12]

Participants

Reactant 2

HCID 62493Pivaloyl chloride

HCID 56839970HCID 56839970, compound

Product 1

HCID 56839978N-(3-amino-4-chloro-2-fluorobenzyl)pivalamideYield 36%

Procedure

The sub-title compound is prepared from crude 3-amino-4-chloro-2-fluoro-benzylamine, 2,2-dimethyl-propionic acid chloride and TEA in analogy to example 5e.

Sources & evidence

ORD record: ord-00aef61d37d848f3b67f9f5eae503a32
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08466186B2

Reaction notes

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