Nitric Acid → 2-Chloro-4-fluoro-5-nitrobenzonitrile

Participants

Reaction Conditions

Reaction Steps

Fuming HNO3 (2.9 mL, 64 mmol) was added dropwise to a solution of 2-chloro-4-fluorobenzonitrile (5.0 g, 32 mmol) in conc. H2SO4 (5 mL) at 0° C. The mixture was stirred at 0° C. for 15 min and at rt for 30 min whereafter it was poured into ice. The precipitate was filtered off, washed with water and dried under vacuum.

Provenance & Evidence