4-chloro-N-methyl-2-nitro-5-(4-(4-trifluoromethylphenyl)-piperazin-1-yl)aniline → 5-Chloro-2-methylamino-4-(4-(4-trifluoromethylphenyl)piperazin-1-yl)aniline

Participants

Reaction Steps

A mixture of 4-chloro-N-methyl-2-nitro-5-(4-(4-trifluoromethylphenyl)-piperazin-1-yl)aniline (200 mg, 0.48 mmol), Ra—Ni (20 mg; 0.34 mmol) and THF (8 mL) was shaken under H2 atmosphere (1 atm) at rt for 4 h. The mixture was filtered through celite and the resulting solution was used immediately used in the next step.

Provenance & Evidence