2,4-Difluoro-N-methyl-6-nitro-3-(4-trifluoromethyl-piperidin-1-yl)aniline → 3,5-Difluoro-2-methylamino-4-(4-trifluoromethyl-piperidin-1-yl)aniline

HRID 1258708Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1258708
[F:1][C:2]1[C:9]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([F:19])([F:18])[F:17])[CH2:12][CH2:11]2)=[C:8]([F:20])[CH:7]=[C:6]([N+:21]([O-])=O)[C:3]=1[NH:4][CH3:5]>[Ni].C1COCC1>[F:1][C:2]1[C:3]([NH:4][CH3:5])=[C:6]([CH:7]=[C:8]([F:20])[C:9]=1[N:10]1[CH2:11][CH2:12][CH:13]([C:16]([F:19])([F:18])[F:17])[CH2:14][CH2:15]1)[NH2:21]

Komponenten

4

Edukt 1

HCID 866743392,4-Difluoro-N-methyl-6-nitro-3-(4-trifluoromethyl-piperidin-1-yl)aniline

Produkt 1

HCID 866743403,5-Difluoro-2-methylamino-4-(4-trifluoromethyl-piperidin-1-yl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 2,4-difluoro-N-methyl-6-nitro-3-(4-trifluoromethyl-piperidin-1-yl)aniline (210 mg, 0.62 mmol), Ra—Ni (4 mg, 0.062 mmol) and THF (30 mL) was shaken under H2 atmosphere (1 atm) at rt for 1 h. The mixture was filtered through celite and the celite pad was further washed with THF. The resulting solution was concentrated to give the sub-title compound.

Aufarbeitung

  1. filtrationThe mixture was filtered through celite
  2. washthe celite pad was further washed with THF
  3. concentrationThe resulting solution was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-9b46f330b3094972b1ee6b43a1453c33
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466186B2

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