HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylcarbodiimide → N-{4-Chloro-3-[5,7-difluoro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | N-(4-Chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide | HCID 86646336 | — |
| Reactant | 3,5-Difluoro-2-methylamino-4-(4-trifluoromethyl-piperidin-1-yl)aniline | HCID 86674340 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-{4-Chloro-3-[5,7-difluoro-1-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanamide | HCID 60162014 | — |
Reaction Steps
The title compound was prepared in analogy to Example 76 using 3,5-difluoro-2-methylamino-4-(4-trifluoromethyl-piperidin-1-yl)aniline (186 mg, 0.60 mmol), N-(4-chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide (200 mg; 0.60 mmol), DIC (76 mg, 0.60 mmol) and DMF (3 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466186B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-7b130626cf6a47e08d32bd055a0d8190 |
| Source note | uspto-grants-2013_06 |