3-(Trifluoromethyl)piperidine → 2-Amino-3-nitro-6-(3-trifluoromethyl-piperidin-1-yl)benzonitrile

Participants

Reaction Steps

A mixture of 2-amino-6-fluoro-3-nitrobenzonitrile (3.1 g, 17 mmol), 3-trifluoromethylpiperidine (2.5 g, 19 mmol), TEA (3.4 g, 34 mmol) and THF (110 mL) was stirred under Ar at rt for 3 h. The mixture was concentrated and poured into H2O and thereafter extracted with EtOAc. The organic layer was dried over Na2SO4, filtered and concentrated. Crystallization from EtOAc gave the sub-title compound.

Provenance & Evidence