1,2-Dichloroethane → N-{4-Chloro-3-[4-cyano-5-(3-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanamide

HRID 1258717ノート

反応式

HRID 1258717 の反応式
[NH2:1][C:2]1[C:9]([NH2:10])=[CH:8][CH:7]=[C:6]([N:11]2[CH2:16][CH2:15][CH2:14][CH:13]([C:17]([F:20])([F:19])[F:18])[CH2:12]2)[C:3]=1[C:4]#[N:5].[Cl:21][C:22]1[CH:38]=[CH:37][C:25]([CH2:26][NH:27][C:28]([C:30]2([C:33]([F:36])([F:35])[F:34])[CH2:32][CH2:31]2)=[O:29])=[CH:24][C:23]=1[N:39]=[C:40]=S.C(Cl)CCl>CN(C=O)C>[Cl:21][C:22]1[CH:38]=[CH:37][C:25]([CH2:26][NH:27][C:28]([C:30]2([C:33]([F:36])([F:35])[F:34])[CH2:31][CH2:32]2)=[O:29])=[CH:24][C:23]=1[NH:39][C:40]1[NH:10][C:9]2[CH:8]=[CH:7][C:6]([N:11]3[CH2:16][CH2:15][CH2:14][CH:13]([C:17]([F:20])([F:18])[F:19])[CH2:12]3)=[C:3]([C:4]#[N:5])[C:2]=2[N:1]=1

参加物

5

反応物 3

HCID 111,2-DichloroethaneHCID 679582702,3-Diamino-6-(3-trifluoromethyl-piperidin-1-yl)benzonitrileHCID 86646336N-(4-Chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide

生成物 1

HCID 60162150N-{4-Chloro-3-[4-cyano-5-(3-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-1-trifluoromethyl-cyclopropanamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The title compound was prepared in analogy to Example 71 using 2,3-diamino-6-(3-trifluoromethyl-piperidin-1-yl)benzonitrile (115 mg, 0.40 mmol), N-(4-chloro-3-isothiocyanatobenzyl)-1-(trifluoromethyl)cyclopropane carboxamide (135 mg; 0.40 mmol), EDC (77 mg, 0.40 mmol) and DMF (3 mL).

出典と根拠

ORDレコード
ord-2904b59c436345e7994c52f010d91238
出典データセット
uspto-grants-2013_06
特許番号
US08466186B2

反応ノート

読み込み中…