HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1258753Generated: November 1, 2026
1,2-Dichloroethane → HCID 178495642, compound
https://huagongshe.com/reaction/1258753
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | (S)-N-(3-(3-(2-Amino-4-chloro-5-(2-(methoxymethyl)pyrrolidin-1-yl)phenyl)thioureido)-4-chlorobenzyl)-1-(trifluoromethyl)cyclopropanecarboxamide | HCID 86674358 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | HCID 178495642 | HCID 178495642 | — |
Reaction Steps
A mixture of (S)—N-(3-(3-(2-amino-4-chloro-5-(2-(methoxymethyl)pyrrolidin-1-yl)phenyl)thioureido)-4-chlorobenzyl)-1-(trifluoromethyl)cyclopropanecarboxamide (110 mg; 0.19 mmol), EDC (36 mg; 0.19 mmol) and DMF (4 mL) was stirred at 90° C. overnight. The mixture was poured into brine and extracted with CH2Cl2. The organic layer was dried over Na2SO4, filtered and concentrated and the residue was purified by column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08466186B2 |
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| Source dataset | uspto-grants-2013_06 |
|---|
| ORD ID | ord-22de824c786a4525be28856cb845512c |
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| Source note | uspto-grants-2013_06 |
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