3-Amino-3-(3,4-dimethoxyphenyl)propanoic acid → Methyl 3-amino-3-(3-cyclopentyloxy-4-methoxy-phenyl)propionate

HRID 1258789ノート

反応式

HRID 1258789 の反応式
N[CH:2](C1C=CC(OC)=C(OC)C=1)CC(O)=O.[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH:32]2[CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:24]=1)[CH2:19][C:20]([OH:22])=[O:21]>>[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH:32]2[CH2:33][CH2:34][CH2:35][CH2:36]2)[CH:24]=1)[CH2:19][C:20]([O:22][CH3:2])=[O:21]

参加物

3

反応物 2

HCID 5971823-Amino-3-(3,4-dimethoxyphenyl)propanoic acidHCID 154354833-Amino-3-(3-cyclopentyloxy-4-methoxyphenyl)propanoic acid

生成物 1

HCID 15435484Methyl 3-amino-3-(3-cyclopentyloxy-4-methoxy-phenyl)propionate

実験手順

The title compound was prepared following the method for preparing Intermediate 6 except that 3-amino-3-(3,4-dimethoxy-phenyl)propionic acid was substituted with 3-amino-3-(3-cyclopentyloxy-4-methoxy-phenyl)propionic acid. 1H NMR (CDCl3): δ 6.78-6.88 (m, 3H), 4.76 (s, 1H), 4.34 (t, 1H, J=5 Hz), 3.80 (s, 3H), 3.66 (s, 3H), 2.62 (d, 2H, J=5 Hz), 1.82-1.92 (m, 8H), 1.58 (s, 2H).

出典と根拠

ORDレコード
ord-f04353b51bce4abf8c90aab1d74f571f
出典データセット
uspto-grants-2013_06
特許番号
US08466191B2

反応ノート

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