3-Amino-3-(3,4-dimethoxyphenyl)propanoic acid → HCID 68468601, compound

HRID 1258790Notes

Reaction equation

HRID 1258790 reaction equation
N[CH:2](C1C=CC(OC)=C(OC)C=1)CC(O)=O.[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:24]=1)[CH2:19][C:20]([OH:22])=[O:21]>>[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH2:32][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:24]=1)[CH2:19][C:20]([O:22][CH3:2])=[O:21]

Participants

3

Reactant 2

HCID 5971823-Amino-3-(3,4-dimethoxyphenyl)propanoic acidHCID 12128624HCID 12128624, compound

Product 1

HCID 68468601HCID 68468601, compound

Procedure

The title compound was prepared following the method for preparing Intermediate 6 except that 3-amino-3-(3,4-dimethoxy-phenyl)propionic acid was substituted with 3-amino-3-(3-benzyloxy-4-methoxy-phenyl)propionic acid. 1H NMR (CDCl3): δ 7.26-7.44 (m, 5H), 6.82-6.93 (m, 3H), 5.13 (s, 2H), 4.31 (t, 1H, J=5 Hz), 3.85 (s, 3H), 3.64 (s, 3H), 2.57 (d, 2H, J=5 Hz), 1.80 (d, 2H, J=5 Hz).

Sources & evidence

ORD record
ord-aa35854f75de4e9ba2ee2d8047be896b
Source dataset
uspto-grants-2013_06
Patent number
US08466191B2

Reaction notes

Loading…