3-Amino-3-(3,4-dimethoxyphenyl)propanoic acid → HCID 68472591, compound

HRID 1258793Notes

Reaction equation

HRID 1258793 reaction equation
N[CH:2](C1C=CC(OC)=C(OC)C=1)CC(O)=O.[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH:30]([CH3:32])[CH3:31])=[C:25]([O:33][CH3:34])[CH:24]=1)[CH2:19][C:20]([OH:22])=[O:21]>>[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH:30]([CH3:32])[CH3:31])=[C:25]([O:33][CH3:34])[CH:24]=1)[CH2:19][C:20]([O:22][CH3:2])=[O:21]

Participants

3

Reactant 2

HCID 5971823-Amino-3-(3,4-dimethoxyphenyl)propanoic acidHCID 3541981HCID 3541981, compound

Product 1

HCID 68472591HCID 68472591, compound

Procedure

The title compound was prepared following the method for preparing Intermediate 6 except that 3-amino-3-(3,4-dimethoxy-phenyl)-propionic acid was substituted with 3-amino-3-(3-methoxy-4-isopropoxy-phenyl)propionic acid. 1H NMR (CDCl3): δ 6.82-6.89 (m, 3H), 4.44-4.51 (m, 1H), 4.35 (t, 1H, J=5 Hz), 3.83 (s, 3H), 3.66 (s, 3H), 2.62 (d, 2H, J=5 Hz), 1.81 (s, 2H), 1.33 (d, 6H, J=5 Hz).

Sources & evidence

ORD record
ord-99e200ea12364e0fa703040f649c7ed0
Source dataset
uspto-grants-2013_06
Patent number
US08466191B2

Reaction notes

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