3-Amino-3-(3,4-dimethoxyphenyl)propanoic acid → Methyl 3-amino-3-(3-methoxy-4-cyclopentyloxy-phenyl)propionate

HRID 1258794Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1258794
N[CH:2](C1C=CC(OC)=C(OC)C=1)CC(O)=O.[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH:30]2[CH2:34][CH2:33][CH2:32][CH2:31]2)=[C:25]([O:35][CH3:36])[CH:24]=1)[CH2:19][C:20]([OH:22])=[O:21]>>[NH2:17][CH:18]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH:30]2[CH2:34][CH2:33][CH2:32][CH2:31]2)=[C:25]([O:35][CH3:36])[CH:24]=1)[CH2:19][C:20]([O:22][CH3:2])=[O:21]

Komponenten

3

Edukt 2

HCID 5971823-Amino-3-(3,4-dimethoxyphenyl)propanoic acidHCID 684666283-Amino-3-(3-methoxy-4-cyclopentyloxy-phenyl)propionic acid

Produkt 1

HCID 68469374Methyl 3-amino-3-(3-methoxy-4-cyclopentyloxy-phenyl)propionate

Versuchsvorschrift

The title compound was prepared following the method for preparing Intermediate 6 except that 3-amino-3-(3,4-dimethoxy-phenyl)-propionic acid was substituted with 3-amino-3-(3-methoxy-4-cyclopentyloxy-phenyl)propionic acid. 1H NMR (CDCl3): δ 6.78-6.88 (m, 3H), 4.69-4.73 (m, 1H), 4.34 (t, 1H, J=5 Hz), 3.82 (s, 3H), 3.66 (s, 3H), 2.62 (d, 2H, J=5 Hz), 1.75-1.92 (m, 8H), 1.58 (s, 2H).

Quellen und Nachweise

ORD-Eintrag
ord-2342c57f65774f4685850147a5ea3d60
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466191B2

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