Water → HCID 57378559, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(4-fluoro-phenyl)-5-(1H-imidazol-4-yl)-1-methyl-1H-[1,2,3]triazole (486 mg, 2.00 mmol), methyl 4-fluorobenzoate (308 mg, 2.00 mmol) and potassium carbonate (553 mg, 4.00 mmol) in DMF (10 mL) was stirred under Ar in a sealed flask and heated at 120° C. for 16 h. After cooling to room temperature the mixture was poured into water and extracted with ethyl acetate and the combined extracts washed with water, brine, dried over sodium sulphate, filtered and evaporated. Purification by chromatography (silica, 0 to 100% ethyl acetate in heptane) afforded the title compound (399 mg, 53%) as a white solid. MS: m/e=378.4 [M+H]+.

Provenance & Evidence