Ammonium Hydroxide → HCID 57378673, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-{4-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-imidazol-1-yl}-benzoic acid (76 mg, 0.209 mmol) in DMF (2 mL) was added CDI (41 mg, 0.251 mmol) and the resulting mixture stirred at 60° C. for 1 h. After cooling to room temperature ammonium hydroxide (330 μL, 2.09 mmol) was added and reaction mixture was stirred for 1 h and then evaporated. Purification by crystallization afforded the title compound (64 mg, 84%) as a white solid. MS: m/e=363.2 [M+H]+.

Provenance & Evidence