4'-Fluoroacetophenone → HCID 57378786, compound

HRID 1258888Notes

Reaction equation

HRID 1258888 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[N:10][N:11]([CH3:18])[C:12]=1[C:13]1[N:14]=[CH:15][NH:16][CH:17]=1.F[C:20]1[CH:25]=[CH:24][C:23]([C:26](=[O:28])[CH3:27])=[CH:22][CH:21]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[N:10][N:11]([CH3:18])[C:12]=1[C:13]1[N:14]=[CH:15][N:16]([C:20]2[CH:25]=[CH:24][C:23]([C:26](=[O:28])[CH3:27])=[CH:22][CH:21]=2)[CH:17]=1

Participants

3

Reactant 2

HCID 98284'-FluoroacetophenoneHCID 178481992HCID 178481992, compound

Product 1

HCID 57378786HCID 57378786, compoundYield 82%

Procedure

As described for example 8e, 4-(2-fluorophenyl)-5-(1H-imidazol-4-yl)-1-methyl-1H-1,2,3-triazole (70 mg, 0.29 mmol), was converted, using 4′-fluoro-acetophenone instead of 4-fluorobenzotrifluoride, to the title compound (85 mg, 82%) which was obtained as an off white solid. MS: m/e=362.2 [M+H]+.

Sources & evidence

ORD record
ord-0d646a275b474a0dba2366eae126bc76
Source dataset
uspto-grants-2013_06
Patent number
US08466181B2

Reaction notes

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