Isopropylamine → HCID 57378902, compound

Participants

Reaction Steps

To a solution of 6-(4-(4-(2-chlorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinic acid (74 mg, 0.194 mmol) and TBTU (69 mg, 0.214 mmol) in DMF (2.0 mL) was added DIPEA (170 μL, 0.972 mmol). Then isopropylamine (19 μL, 0.214 mmol) was added and the mixture was stirred at room temperature under Ar for 2 h. The mixture was then evaporated and purification by chromatography (silica, 50 to 100% ethyl acetate in heptane) afforded the title compound (52 mg, 63%) as a white solid. MS: m/e=422.1 [M+H]+.

Provenance & Evidence