Ammonium Hydroxide → HCID 57378903, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-(4-(4-(2-chlorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinic acid (74 mg, 0.194 mmol) in DMF (3 mL) was added CDI (38 mg, 0.233 mmol) and the resulting mixture stirred at 60° C. for 1 h. After cooling to room temperature ammonium hydroxide (305 μL, 1.94 mmol) was added and reaction mixture was stirred for 1 h and then evaporated. Purification by chromatography (reverse phase HPLC) afforded the title compound (54 mg, 73%) as a white foam. MS: m/e=380.1 [M+H]+.

Provenance & Evidence