Lithium hydroxide, monohydrate → HCID 57378905, compound

Participants

Reaction Steps

A solution of lithium hydroxide monohydrate (63 mg, 1.49 mmol) in water (3.0 mL) was added dropwise to a suspension of methyl 6-(4-(4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinate (282 mg, 0.745 mmol) in THF (6.0 mL) and methanol (1 mL). The reaction mixture was then stirred at room temperature for 1.5 h and was then evaporated and the residue dissolved in water, acidified with HCl (1 N), and the resulting precipitate filtered off to afford the title product (244 mg, 90%) as a white solid. MS: m/e=363.3 [M−H]−.

Provenance & Evidence