Isopropylamine → HCID 57377258, compound

HRID 1258898Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[N:10][N:11]([CH3:27])[C:12]=1[C:13]1[N:14]=[CH:15][N:16]([C:18]2[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][N:19]=2)[CH:17]=1.[CH:28]([NH2:31])([CH3:30])[CH3:29]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[N:10][N:11]([CH3:27])[C:12]=1[C:13]1[N:14]=[CH:15][N:16]([C:18]2[CH:26]=[CH:25][C:21]([C:22]([NH:31][CH:28]([CH3:30])[CH3:29])=[O:23])=[CH:20][N:19]=2)[CH:17]=1

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 57378905HCID 57378905, compound

Product 1

HCID 57377258HCID 57377258, compoundYield 61%

Procedure

As described for example 22, 6-(4-(4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinic acid (75 mg, 0.194 mmol) was converted, using isopropylamine instead of 4-aminotetrahydropyran, to the title compound (51 mg, 61%) which was obtained as an off white foam. MS: m/e=406.3 [M+H]+.

Sources & evidence

ORD record: ord-f57f72ae569b419d88cd07e5e6c3c9a4
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08466181B2

Reaction notes

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