3-Amino-3-methyloxetane → HCID 57377262, compound

HRID 1258900Notes

Reaction equation

HRID 1258900 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[N:10][N:11]([CH3:27])[C:12]=1[C:13]1[N:14]=[CH:15][N:16]([C:18]2[CH:26]=[CH:25][C:21]([C:22]([OH:24])=O)=[CH:20][N:19]=2)[CH:17]=1.[CH3:28][C:29]1([NH2:33])[CH2:32][O:31][CH2:30]1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[N:10][N:11]([CH3:27])[C:12]=1[C:13]1[N:14]=[CH:15][N:16]([C:18]2[CH:26]=[CH:25][C:21]([C:22]([NH:33][C:29]3([CH3:28])[CH2:32][O:31][CH2:30]3)=[O:24])=[CH:20][N:19]=2)[CH:17]=1

Participants

3

Reactant 2

HCID 468357253-Amino-3-methyloxetaneHCID 57378905HCID 57378905, compound

Product 1

HCID 57377262HCID 57377262, compoundYield 74%

Procedure

As described for example 22, 6-(4-(4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinic acid (69 mg, 0.189 mmol) was converted, using 3-methyl-3-oxetaneamine instead of 4-aminotetrahydropyran, to the title compound (61 mg, 74%) which was obtained as a white foam after purification by chromatography (silica, 0 to 10% methanol in dichloromethane). MS: m/e=434.3 [M+H]+.

Sources & evidence

ORD record
ord-fc2814d8198945edbae7fbc188e3055f
Source dataset
uspto-grants-2013_06
Patent number
US08466181B2

Reaction notes

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