Cyclopropylamine → HCID 57377364, compound

HRID 1258902Notes

Reaction equation

HRID 1258902 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]=[N:10][N:11]([CH3:27])[C:12]=1[C:13]1[N:14]=[CH:15][N:16]([C:18]2[CH:26]=[CH:25][C:21]([C:22]([OH:24])=O)=[CH:20][N:19]=2)[CH:17]=1.[CH:28]1([NH2:31])[CH2:30][CH2:29]1>>[CH:28]1([NH:31][C:22](=[O:24])[C:21]2[CH:25]=[CH:26][C:18]([N:16]3[CH:17]=[C:13]([C:12]4[N:11]([CH3:27])[N:10]=[N:9][C:8]=4[C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=4[F:1])[N:14]=[CH:15]3)=[N:19][CH:20]=2)[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 57378905HCID 57378905, compound

Product 1

HCID 57377364HCID 57377364, compoundYield 56%

Procedure

As described for example 22, 6-(4-(4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinic acid (69 mg, 0.189 mmol) was converted, using cyclopropylamine instead of 4-aminotetrahydropyran, to the title compound (43 mg, 56%) which was obtained as a white foam. MS: m/e=404.4 [M+H]+.

Sources & evidence

ORD record
ord-6f77ec4de3b54bf993806d0d7f31df7c
Source dataset
uspto-grants-2013_06
Patent number
US08466181B2

Reaction notes

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