Bromine → 2-Bromo-1-(1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)ethanone

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Reaction Steps

A solution of 1-(1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)ethanone (1.66 g, 7.57 mmol) was dissolved in chloroform (12 mL) and acetic (0.24 mL) was heated to reflux and then a solution of bromine (0.41 mL, 7.95 mmol) in chloroform (5 mL) and heated under reflux for 2 h and then bromine (0.12 mL, 2.27 mmol) in chloroforom (2 mL) was added and heated under reflux for a further 30 min. After cooling to room temperature the mixture was poured onto ice-water and the mixture extracted with dichloromethane. The combined organic extracts were washed with water, brine, dried over sodium sulphate, filtered and evaporated. Purification by chromatography (silica, 10 to 60% ethyl acetate in heptane) afforded the title compound (1.54 g, 64%) as an off white solid. MS: m/e=298.1/300.0 [M+H]+.

Provenance & Evidence