Lithium hydroxide, monohydrate → HCID 67956048, compound

Participants

Reaction Steps

A solution of lithium hydroxide monohydrate (62 mg, 1.46 mmol) in water (2.8 mL) was added dropwise to a suspension of methyl 6-(4-(1-(4-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinate (277 mg, 0.732 mmol) in THF (4.8 mL) and methanol (1 mL). The reaction mixture was then stirred at room temperature for 1 h and was then evaporated and the residue dissolved in water, acidified with HCl (1 N), and the resulting precipitate filtered off to afford the title product (245 mg, 92%) as a light brown solid. MS: m/e=363.2 [M−H]−.

Provenance & Evidence