Isopropylamine → HCID 57377474, compound

Participants

Reaction Steps

To a solution of 6-(4-(1-(4-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinic acid (56 mg, 0.154 mmol) and TBTU (55 mg, 0.169 mmol) in DMF (2.0 mL) was added DIPEA (131 μL, 0.769 mmol). Then isopropylamine (15 μL, 0.169 mmol) was added and the mixture was stirred at room temperature under Ar for 1 h. The mixture was then evaporated and purification by chromatography (silica, 50 to 100% ethyl acetate in heptane) afforded the title compound (47 mg, 75%) as a white solid. MS: m/e=406.4 [M+H]+.

Provenance & Evidence