Ammonium Hydroxide → HCID 57377581, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-(4-(1-(4-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinic acid (70 mg, 0.192 mmol) in DMF (2 mL) was added CDI (38 mg, 0.231 mmol) and the resulting mixture stirred at 60° C. for 1 h. After cooling to room temperature ammonium hydroxide (300 μL, 1.92 mmol) was added and reaction mixture was stirred for 16 h and then evaporated. Purification by chromatography (silica, 50 to 100% ethyl acetate in heptane) afforded the title compound (61 mg, 87%) as an off white solid. MS: m/e=364.3 [M+H]+.

Provenance & Evidence