Cyclopropylamine → HCID 57336779, compound

HRID 1258923Notes

Reaction equation

HRID 1258923 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[N:14]=[CH:15][N:16]([C:18]4[CH:26]=[CH:25][C:21]([C:22]([OH:24])=O)=[CH:20][N:19]=4)[CH:17]=3)=[C:11]([CH3:27])[N:10]=[N:9]2)=[CH:4][CH:3]=1.[CH:28]1([NH2:31])[CH2:30][CH2:29]1>>[CH:28]1([NH:31][C:22](=[O:24])[C:21]2[CH:25]=[CH:26][C:18]([N:16]3[CH:17]=[C:13]([C:12]4[N:8]([C:5]5[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=5)[N:9]=[N:10][C:11]=4[CH3:27])[N:14]=[CH:15]3)=[N:19][CH:20]=2)[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 67956048HCID 67956048, compound

Product 1

HCID 57336779HCID 57336779, compoundYield 38%

Procedure

As described for example 36b, 6-(4-(1-(4-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinic acid (65 mg, 0.178 mmol) was converted, using cyclopropylamine instead of isopropylamine, to the title compound (27 mg, 38%) which was obtained as an off white solid. MS: m/e=404.2 [M+H]+.

Sources & evidence

ORD record
ord-440653919c294453afc23e2f4a4e898a
Source dataset
uspto-grants-2013_06
Patent number
US08466181B2

Reaction notes

Loading…