Isopropylamine → HCID 57377583, compound

Participants

Reaction Steps

To a solution of 6-(4-(1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinic acid (46 mg, 0.126 mmol) and TBTU (45 mg, 0.139 mmol) in DMF (2.0 mL) was added DIPEA (110 μL, 0.631 mmol). Then isopropylamine (12 μL, 0.139 mmol) was added and the mixture was stirred at room temperature under Ar for 2 h. The mixture was then evaporated and purification by chromatography (silica, 50 to 100% ethyl acetate in heptane) afforded the title compound (34 mg, 66%) as a white foam. MS: m/e=406.3 [M+H]+.

Provenance & Evidence