4-Aminotetrahydropyran → HCID 57377586, compound

Participants

Reaction Steps

As described for example 43c, 6-(4-(1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)-1H-imidazol-1-yl)nicotinic acid (46 mg, 0.126 mmol) was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (41 mg, 73%) which was obtained as a white foam after purification by chromatography (silica, 0-10% methanol in dichloromethane). MS: m/e=448.2 [M+H]+.

Provenance & Evidence