反应详情

To a stirring solution of ethyl 3-(benzylamino)-4-nitrobenzoate (1.52 g, 5 mmol) in ethanol (50 mL) and acetic acid (7 mL) was added zinc dust (2.3 g, 35 mmol). After 1 hr at room temperature, the solids were filtered and the remaining solution was concentrated. The resulting residue was diluted with ethyl acetate (200 mL) and washed with dilute aq. NaHCO3 (1×100 mL), then the organic layer was dried (MgSO4), filtered and then concentrated to provide 1.44 g (˜100%) of crude ethyl 4-amino-3-(benzylamino)benzoate as an orange/brown oil. This material was used without further purification.

1. filtrationthe solids were filtered
2. concentrationthe remaining solution was concentrated
3. additionThe resulting residue was diluted with ethyl acetate (200 mL)
4. washwashed with dilute aq. NaHCO3 (1×100 mL)
5. dry with materialthe organic layer was dried (MgSO4)
6. filtrationfiltered
7. concentrationconcentrated