4-(2-Bromoethoxy)Benzaldehyde → methyl 1-(2-(4-formylphenoxy)ethyl)-1H-indole-6-carboxylate

HRID 1258944Notes

Reaction equation

HRID 1258944 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([O:12][CH3:13])=[O:11])[CH:8]=2)[CH:3]=[CH:2]1.Br[CH2:15][CH2:16][O:17][C:18]1[CH:25]=[CH:24][C:21]([CH:22]=[O:23])=[CH:20][CH:19]=1>>[CH:22]([C:21]1[CH:24]=[CH:25][C:18]([O:17][CH2:16][CH2:15][N:1]2[C:9]3[C:4](=[CH:5][CH:6]=[C:7]([C:10]([O:12][CH3:13])=[O:11])[CH:8]=3)[CH:3]=[CH:2]2)=[CH:19][CH:20]=1)=[O:23]

Participants

3

Reactant 2

HCID 2627064-(2-Bromoethoxy)BenzaldehydeHCID 639844Methyl indole-6-carboxylate

Product 1

HCID 58213818methyl 1-(2-(4-formylphenoxy)ethyl)-1H-indole-6-carboxylate

Procedure

Methyl 1H-indole-6-carboxylate was alkylated with 4-(2-bromoethoxy)benzaldehyde as described in Example 3, Step 1 to provide methyl 1-(2-(4-formylphenoxy)ethyl)-1H-indole-6-carboxylate.

Sources & evidence

ORD record
ord-454eb29a668d42c1834c8745d253091e
Source dataset
uspto-grants-2013_06
Patent number
US08466193B2

Reaction notes

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