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4-(Bromomethyl)benzoic acid → 4-Ethoxymethyl-benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Bromomethyl)benzoic acid | HCID 22599 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-But-3-enyloxymethyl-benzoic acid | HCID 22136996 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Ethoxymethyl-benzoic acid | HCID 308541 | — |
反応手順
The reaction of ethanol and 4-Bromomethyl-benzoic acid in the presence of sodium hydride was performed as described for Compound 33 to give 4-Ethoxymethyl-benzoic acid as white powder. 1H-NMR (400 MHz, d6-DMSO): 7.89 (d, J=8.2, 2 arom.H); 7.40 (d, J=8.2, 2 arom.H); 4.50 (s, OCH2C6H4); 3.49 (q, J=6.9, CH3CH2); 1.15 (t, J=6.9, CH3CH2). 13C-NMR (100 MHz, d6-DMSO): 167.24 (—C═O); 143.88; 129.65; 129.28 (2 arom. C); 127.05 (2 arom. C); 70.95; 65.25; 15.06.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08466199B2 |
| 出典データセット | uspto-grants-2013_06 |
| ORD ID | ord-b4e0bcd9b4ca41eb85916ba920ce49a9 |
| 出典メモ | uspto-grants-2013_06 |