4-(Bromomethyl)benzoic acid → 4-(Propoxymethyl)benzoic acid

Participants

Reaction Steps

The reaction of propanol and 4-Bromomethyl-benzoic acid in the presence of sodium hydride was performed as described for Compound 33 to give 4-propoxymethyl-benzoic acid as white powder. 1H-NMR (400 MHz, d6-DMSO): 7.89 (d, J=8.2, 2 arom.H); 7.40 (d, J=8.2, 2 arom.H); 4.50 (s, OCH2C6H4—); 3.38 (t, CH3CH2CH2O); 1.54 (m, CH3CH2CH2O); 0.87 (t, CH3CH2CH2O).). 13C-NMR (100 MHz, d6-DMSO): 167.24 (—C═O); 143.94; 129.67; 129.30 (2 arom. C); 127.03 (2 arom. C); 71.53; 71.13; 22.43; 10.55.

Provenance & Evidence