HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 3-(ethoxymethyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-(Chloromethyl)benzoic acid | HCID 241752 | — |
| Reactant | 4-But-3-enyloxymethyl-benzoic acid | HCID 22136996 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(ethoxymethyl)benzoic acid | HCID 17606044 | — |
Reaction Steps
The reaction of ethanol and 3-Chloromethyl-benzoic acid in the presence of sodium hydride was performed as described for Compound 33 to give 3-ethoxymethyl-benzoic acid as white powder. 1H-NMR (400 MHz, d6-DMSO): 7.89 (m, 1 arom.H); 7.84 (m, 1 arom.H); 7.54 (m, 1 arom.H); 7.46 (m, 1 arom.H); 4.49 (s, OCH2C6H4—); 3.48 (q, J=6.9, CH3CH2); 1.15 (t, J=6.9, CH3CH2). 13C-NMR (100 MHz, d6-DMSO): 167.24 (—C═O); 139.26; 131.67; 130.76; 128.51; 128.23; 128.06; 71.01; 65.14; 15.07.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466199B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-b9efb6f7f1bb4b80a53236949d2391a4 |
| Source note | uspto-grants-2013_06 |