HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 3-Isopropoxymethyl-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-(Chloromethyl)benzoic acid | HCID 241752 | — |
| Reactant | 4-But-3-enyloxymethyl-benzoic acid | HCID 22136996 | — |
| Product | 3-Isopropoxymethyl-benzoic acid | HCID 24710664 | — |
Reaction Steps
The reaction of isopropanol and 3-Chloromethyl-benzoic acid in the presence of sodium hydride was performed as described for Compound 33 to give 3-isopropoxymethyl-benzoic acid as white powder. 1H-NMR (400 MHz, d6-DMSO): 7.89 (m, 1 arom.H); 7.84 (m, 1 arom.H); 7.54 (m, 1 arom.H); 7.46 (m, 1 arom.H); 4.49 (s, OCH2C6H4—); 3.653 (m, CH(CH3)2); 1.14 (d, CH(CH3)2). 13C-NMR (100 MHz, d6-DMSO): 167.24 (—C═O); 139.79; 131.56; 130.68; 128.43; 128.08; 127.92; 70.54; 68.50; 22.02 (2 C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466199B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-15aff13f0bdd448d81a4e593764e10d8 |
| Source note | uspto-grants-2013_06 |