反应详情

A 500-ml three-necked round flask equipped with a stirring bar, a Dimroth condenser, a thermometer and a NaOH trap was charged with 277 mmol of 3-(2-bromophenyl)-2-propylpropionic acid and 200 ml of thionyl chloride, and the mixture was heated under reflux for 2 hours. Then, the excess thionyl chloride was removed by a single distillation, and the distillation of the residue under reduced pressure gave 77.4 g of a crude product having a boiling point of 130° to 135° C./1 mmHg as a pale brown transparent liquid. This acid chloride was used in the next reaction without further purification

1. customA 500-ml three-necked round flask equipped with a stirring bar
2. temperaturethe mixture was heated
3. temperatureunder reflux for 2 hours
4. customThen, the excess thionyl chloride was removed by a single distillation
5. distillationthe distillation of the residue under reduced pressure