Sodium Hydroxide → HCID 23582291, compound

HRID 1259035Notes

Reaction equation

HRID 1259035 reaction equation
C[O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH:10][C:11]([NH:13][CH:14]2[CH:21]3[CH2:22][CH:17]4[CH2:18][CH:19]([CH2:23][CH:15]2[CH2:16]4)[CH2:20]3)=[O:12])[C:5]=1[CH3:24].[OH-].[Na+]>CO>[CH:15]12[CH2:23][CH:19]3[CH2:18][CH:17]([CH2:22][CH:21]([CH2:20]3)[CH:14]1[NH:13][C:11](=[O:12])[NH:10][C:6]1[C:5]([CH3:24])=[C:4]([CH:9]=[CH:8][CH:7]=1)[C:3]([OH:25])=[O:2])[CH2:16]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23582033HCID 23582033, compound

Product 1

HCID 23582291HCID 23582291, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3-(3-Adamantan-2-yl-ureido)-2-methyl-benzoic acid methyl ester 70 mg (0.204 mmol), 0.408 ml NaOH 1N in 2 ml methanol was stirred overnight at 55° C. The mixture was concentrated, diluted with water and extracted with ethyl acetate. The aqueous phase was acidified to pH 1 and the precipitate was filtered and dried under vacuum to give 53 mg (79%) as white solid.

Workup

  1. concentrationThe mixture was concentrated
  2. additiondiluted with water
  3. extractionextracted with ethyl acetate
  4. filtrationthe precipitate was filtered
  5. customdried under vacuum
  6. customto give 53 mg (79%) as white solid

Sources & evidence

ORD record
ord-20f60deb622c40848501c8df996028af
Source dataset
uspto-grants-2013_06
Patent number
US08466200B2

Reaction notes

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