N-[2-(2-hydroxyethoxy)ethyl]-1-(2-nitrophenyl)methanesulfonamide → 1-(2-aminophenyl)-N-[2-(2-hydroxyethoxy)ethyl]methanesulfonamide

HRID 1259038노트

반응식

HRID 1259038 반응식
[OH:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][NH:7][S:8]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N+:18]([O-])=O)(=[O:10])=[O:9]>CO.[Pd]>[NH2:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][S:8]([NH:7][CH2:6][CH2:5][O:4][CH2:3][CH2:2][OH:1])(=[O:10])=[O:9]

참가 물질

4

반응물 1

HCID 62498280N-[2-(2-hydroxyethoxy)ethyl]-1-(2-nitrophenyl)methanesulfonamide

생성물 1

HCID 625000681-(2-aminophenyl)-N-[2-(2-hydroxyethoxy)ethyl]methanesulfonamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a stirred solution of N-[2-(2-hydroxyethoxy)ethyl]-1-(2-nitrophenyl)-methanesulfonamide (0.145 g, 0.48 mmol) in methanol (10 ml) under an atmosphere of nitrogen was added 10% Pd/C (10 Wt %, 15 mg) in one portion. The reaction was evacuated, placed under an atmosphere of hydrogen (1 bar) and stirred vigorously overnight. The reaction was filtered through celite and the filtrate was concentrated in vacuo to afford 1-(2-aminophenyl)-N-[2-(2-hydroxyethoxy)ethyl]methanesulfonamide as product (0.105 g, 81%); LCMS Rt=2.06 min, m/z (APCI) 297 (M+Na).

후처리

  1. customThe reaction was evacuated
  2. filtrationThe reaction was filtered through celite
  3. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-653a82e59ad947e2bfaa24ccae6eb61c
출처 데이터셋
uspto-grants-2013_06
특허 번호
US08466201B2

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