反应详情

To a stirred solution of N-[2-(2-hydroxyethoxy)ethyl]-1-(2-nitrophenyl)-methanesulfonamide (0.145 g, 0.48 mmol) in methanol (10 ml) under an atmosphere of nitrogen was added 10% Pd/C (10 Wt %, 15 mg) in one portion. The reaction was evacuated, placed under an atmosphere of hydrogen (1 bar) and stirred vigorously overnight. The reaction was filtered through celite and the filtrate was concentrated in vacuo to afford 1-(2-aminophenyl)-N-[2-(2-hydroxyethoxy)ethyl]methanesulfonamide as product (0.105 g, 81%); LCMS Rt=2.06 min, m/z (APCI) 297 (M+Na).

1. customThe reaction was evacuated
2. filtrationThe reaction was filtered through celite
3. concentrationthe filtrate was concentrated in vacuo