HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1259114Generated: November 2, 2026
Dimethylformamide → Ethyl 5-chloro-6-cyanonicotinate
https://huagongshe.com/reaction/1259114
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Ethyl 5,6-Dichloronicotinate | HCID 16762519 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Product | Ethyl 5-chloro-6-cyanonicotinate | HCID 66875248 | — |
Reaction Steps
A solution of ethyl 5,6-dichloronicotinate (1 eq), zinc cyanide (0.75 eq) and tetrakis(triphenyl-phosphine)palladium (0.10 eq.) in DMF (0.3 M) was degassed and then heated at 100° C. for 3 hours. Solvent was removed en vaccuo to obtain a crude residue. The crude material was purified by flash chromatography on a COMBIFLASH® system (ISCO) using 0-80% ethyl acetate in hexane to give ethyl 5-chloro-6-cyanonicotinate as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08466167B2 |
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| Source dataset | uspto-grants-2013_06 |
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| ORD ID | ord-0aa5aa103a0f40f08f3077c14f9d2bb4 |
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| Source note | uspto-grants-2013_06 |
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