HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1259132Generated: November 2, 2026
Di-tert-butyl dicarbonate → tert-Butyl 5,6-dichloropyridin-3-ylcarbamate
https://huagongshe.com/reaction/1259132
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | 5-Amino-2,3-dichloropyridine | HCID 14595219 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | tert-Butyl 5,6-dichloropyridin-3-ylcarbamate | HCID 22485189 | — |
Reaction Steps
To a solution of 5,6-dichloropyridin-3-amine (commercially available) in THF (0.2 M) stirred at 0° C. was added (BOC)2O (1.2 eq). The reaction mixture was heated at 40° C. until full conversion as monitored by TLC. The reaction mixture was then concentrated. Flash chromatography (silica gel, 20-50% EtOAc in hexanes) of the crude afforded tert-butyl 5,6-dichloropyridin-3-ylcarbamate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08466167B2 |
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| Source dataset | uspto-grants-2013_06 |
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| ORD ID | ord-7bd85b19beae4f5291a6e7925bf2d501 |
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| Source note | uspto-grants-2013_06 |
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