Thionyl Chloride → HCID 86652358, compound

HRID 1259202Notes

Reaction equation

HRID 1259202 reaction equation
[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8]([CH2:12][CH2:13][C:14]3[CH:22]=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][C:15]=3[CH3:23])=[CH:7][C:6]=2[C:5]2[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:4]=2[N:3]=1.S(Cl)([Cl:31])=O>>[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8]([CH2:12][CH2:13][C:14]3[CH:22]=[CH:21][C:17]([C:18]([Cl:31])=[O:19])=[CH:16][C:15]=3[CH3:23])=[CH:7][C:6]=2[C:5]2[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 58213539HCID 58213539, compound

Product 1

HCID 86652358HCID 86652358, compound

Procedure

A solution of 4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylbenzoic acid (from the previous step) in thionyl chloride was stirred at 60° C. for 3 hour. After cooling to ambient temperature, the reaction mixture was concentrated en vaccuo. The crude material was used for next step without purification.

Workup

  1. concentrationthe reaction mixture was concentrated en vaccuo
  2. customThe crude material was used for next step without purification

Sources & evidence

ORD record
ord-39b17fa39e814a9b90b5e63d0baff5a5
Source dataset
uspto-grants-2013_06
Patent number
US08466167B2

Reaction notes

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