反应详情

温度

60 °C

Methyl 6-[1-(4-chlorophenyl)-pyrazol-5-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate (0.0915 g, 0.187 mmol) was dissolved in 7M ammonia in methanol (4.0 mL, 28 mmol) and heated in a microwave reactor (Biotage) at 60° C. for 7 minutes. The violet coloured solution was concentrated by rotary evaporation. The crude product was purified by semi-preparative reversed phase-HPLC (Kromasil C18 column) with acetonitrile-water (60 to 97% MeCN) as eluent to give 6-[1-(4-chlorophenyl)-1H-pyrazol-5-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide (0.0636 g, 72%) as a light yellow solid.

1. concentrationwas concentrated by rotary evaporation
2. customThe crude product was purified by semi-preparative reversed phase-HPLC (Kromasil C18 column) with acetonitrile-water (60 to 97% MeCN) as eluent