Cyclopropanesulfonyl chloride → HCID 67346186, compound

Participants

Reaction Steps

Following the procedure set forth for the preparation of Example 1A, 8-amino-1-benzyl-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one (250 mg, 0.001 mol) in pyridine (4 mL) was reacted with cyclopropanesulfonyl chloride (144 mg, 0.001 mol) to afford the crude product. Purification by column chromatography on silica gel (80% ethylacetate in hexane) afforded 40 mg of the product (13.2% yield).

Provenance & Evidence