HCID 67346186, compound → HCID 52934783, compound

HRID 1259368Notes

Reaction equation

HRID 1259368 reaction equation
C([N:8]1[C:12]2=[C:13]([NH:28][S:29]([CH:32]3[CH2:34][CH2:33]3)(=[O:31])=[O:30])[C:14]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([I:26])=[CH:22][C:21]=3[F:27])=[C:15]([CH3:18])[C:16](=[O:17])[N:11]2[CH2:10][CH2:9]1)C1C=CC=CC=1>C(Cl)Cl>[F:27][C:21]1[CH:22]=[C:23]([I:26])[CH:24]=[CH:25][C:20]=1[NH:19][C:14]1[C:13]([NH:28][S:29]([CH:32]2[CH2:33][CH2:34]2)(=[O:31])=[O:30])=[C:12]2[NH:8][CH2:9][CH2:10][N:11]2[C:16](=[O:17])[C:15]=1[CH3:18]

Participants

3

Reactant 1

HCID 67346186HCID 67346186, compound

Product 1

HCID 52934783HCID 52934783, compoundYield 9.09%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the procedure set forth for the preparation of Example 2A, cyclopropanesulfonic acid [1-benzyl-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-imidazo[1,2-a]pyridin-8-yl]-amide (40 mg, 0.0001 mol) in DCM (3 mL) was reacted with borontribromide (0.025 g, 0.0001 mol) to afford the crude product. Purification by column chromatography on silica gel (4% methanol in CHCl3) afforded 3 mg of the product (9.09% yield).

Workup

  1. customwas reacted with borontribromide (0.025 g, 0.0001 mol)
  2. customto afford the crude product
  3. customPurification by column chromatography on silica gel (4% methanol in CHCl3)

Sources & evidence

ORD record
ord-67a2caee703447e993a3db92bceab267
Source dataset
uspto-grants-2013_06
Patent number
US08466289B2

Reaction notes

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